Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior.
Ruyle BC, Masud S, Kesaraju R, Tahirkheli M, Modh J, Roth CG, Angulo-Lopera S, Lintz T, Higginbotham JA, Massaly N, Morón JA.
Elife. 2025 Apr 1;13:RP104469. doi: 10.7554/eLife.104469.
PMID: 40167443
An autonomous implantable device for the prevention of death from opioid overdose.
Ciatti JL, Vázquez-Guardado A, Brings VE, Park J, Ruyle B, Ober RA, McLuckie AJ, Talcott MR, Carter EA, Burrell AR, Sponenburg RA, Trueb J, Gupta P, Kim J, Avila R, Seong M, Slivicki RA, Kaplan MA, Villalpando-Hernandez B, Massaly N, Montana MC, Pet M, Huang Y, Morón JA, Gereau RW 4th, Rogers JA.
Sci Adv. 2024 Oct 25;10(43):eadr3567. doi: 10.1126/sciadv.adr3567. Epub 2024 Oct 23.
PMID: 39441938
Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry.
Kwok CHT, Harding EK, Burma NE, Markovic T, Massaly N, van den Hoogen NJ, Stokes-Heck S, Gambeta E, Komarek K, Yoon HJ, Navis KE, McAllister BB, Canet-Pons J, Fan C, Dalgarno R, Gorobets E, Papatzimas JW, Zhang Z, Kohro Y, Anderson CL, Thompson RJ, Derksen DJ, Morón JA, Zamponi GW, Trang T.
Nat Commun. 2024 Jul 24;15(1):6264. doi: 10.1038/s41467-024-50657-7.
PMID: 39048565
A locus coeruleus to dorsal hippocampus pathway mediates cue-induced reinstatement of opioid self-administration in male and female rats.
Markovic T, Higginbotham J, Ruyle B, Massaly N, Yoon HJ, Kuo CC, Kim JR, Yi J, Garcia JJ, Sze E, Abt J, Teich RH, Dearman JJ, McCall JG, Morón JA.
Neuropsychopharmacology. 2024 May;49(6):915-923. doi: 10.1038/s41386-024-01828-z. Epub 2024 Feb 19.
PMID: 38374364
Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons.
Massaly N*, Ibrahim KM*, Yoon HJ, Sandoval R, Widman AJ, Heuermann RJ, Williams S, Post W, Pathiranage S, Lintz T, Zec A, Park A, Yu W, Kash TL, Gereau RW 4th, Morón JA.
Nat Commun. 2024 Jan 29;15(1):750. doi: 10.1038/s41467-024-44836-9.
PMID: 38286800
Endogenous opioid systems alterations in pain and opioid use disorder.
Higginbotham JA, Markovic T, Massaly N, Morón JA.
Front Syst Neurosci. 2022 Oct 19;16:1014768. doi: 10.3389/fnsys.2022.1014768. eCollection 2022.
PMID: 36341476
Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior.
Markovic T, Pedersen CE, Massaly N, Vachez YM, Ruyle B, Murphy CA, Abiraman K, Shin JH, Garcia JJ, Yoon HJ, Alvarez VA, Bruchas MR, Creed MC, Morón JA.
Nat Neurosci. 2021 Nov;24(11):1601-1613. doi: 10.1038/s41593-021-00924-3. Epub 2021 Oct 18.
PMID: 34663957
Behavioral outcomes of complete Freund adjuvant-induced inflammatory pain in the rodent hind paw: a systematic review and meta-analysis.
Burek DJ, Massaly N, Yoon HJ, Doering M, Morón JA.
Pain. 2022 May 1;163(5):809-819. doi: 10.1097/j.pain.0000000000002467.
PMID: 34510137
Pain, negative affective states and opioid-based analgesics: Safer pain therapies to dampen addiction.
Massaly N, Markovic T, Creed M, Al-Hasani R, Cahill CM, Moron JA.
Int Rev Neurobiol. 2021;157:31-68. doi: 10.1016/bs.irn.2020.09.002. Epub 2021 Feb 2.
PMID: 33648672
Long-term inflammatory pain does not impact exploratory behavior and stress coping strategies in mice.
Burek DJ, Massaly N, Doering M, Zec A, Gaelen J, Morón JA.
Pain. 2021 Jun 1;162(6):1705-1721. doi: 10.1097/j.pain.0000000000002179.
PMID: 33433146
Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template.
Faouzi A, Uprety R, Gomes I, Massaly N, Keresztes AI, Le Rouzic V, Gupta A, Zhang T, Yoon HJ, Ansonoff M, Allaoa A, Pan YX, Pintar J, Morón JA, Streicher JM, Devi LA, Majumdar S.J
Med Chem. 2020 Nov 25;63(22):13618-13637. doi: 10.1021/acs.jmedchem.0c00901. Epub 2020 Nov 10.
PMID: 33170687
Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of non evoked ongoing pain.
Massaly N, Temp J, Machelska H, Stein C.
Pain. 2020 Dec;161(12):2798-2804. doi: 10.1097/j.pain.0000000000001968.
PMID: 32639370
Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue.
Meyer J, Del Vecchio G, Seitz V, Massaly N, Stein C.
Br J Pharmacol. 2019 Dec;176(23):4510-4520. doi: 10.1111/bph.14810. Epub 2019 Dec 5.
PMID: 31355457
Pain-Induced Negative Affect Is Mediated via Recruitment of The Nucleus Accumbens Kappa Opioid System.
Massaly N, Copits BA, Wilson-Poe AR, Hipólito L, Markovic T, Yoon HJ, Liu S, Walicki MC, Bhatti DL, Sirohi S, Klaas A, Walker BM, Neve R, Cahill CM, Shoghi KI, Gereau RW 4th, McCall JG, Al-Hasani R, Bruchas MR, Morón JA.
Neuron. 2019 May 8;102(3):564-573.e6. doi: 10.1016/j.neuron.2019.02.029. Epub 2019 Mar 13.
PMID: 30878290
A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System.
Massaly N, Morón JA, Al-Hasani R.
Front Neurosci. 2016 Nov 7;10:480. doi: 10.3389/fnins.2016.00480. eCollection 2016.
PMID: 27872581
Morphine-Associated Contextual Cues Induce Structural Plasticity in Hippocampal CA1 Pyramidal Neurons.
Fakira AK, Massaly N, Cohensedgh O, Berman A, Morón JA.
Neuropsychopharmacology. 2016 Oct;41(11):2668-78. doi: 10.1038/npp.2016.69. Epub 2016 May 10.
PMID: 27170097
Roles of the ubiquitin proteasome system in the effects of drugs of abuse.
Massaly N, Francès B, Moulédous L.
Front Mol Neurosci. 2015 Jan 6;7:99. doi: 10.3389/fnmol.2014.00099. eCollection 2014.
PMID: 25610367
Involvement of protein degradation by the ubiquitin proteasome system in opiate addictive behaviors.
Massaly N, Dahan L, Baudonnat M, Hovnanian C, Rekik K, Solinas M, David V, Pech S, Zajac JM, Roullet P, Mouledous L, Frances B.
Neuropsychopharmacology. 2013 Mar;38(4):596-604. doi: 10.1038/npp.2012.217. Epub 2012 Nov 21.
PMID: 23169349
Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice.
Duparc T, Colom A, Cani PD, Massaly N, Rastrelli S, Drougard A, Le Gonidec S, Moulédous L, Frances B, Leclercq I, Llorens-Cortes C, Pospisilik JA, Delzenne NM, Valet P, Castan-Laurell I, Knauf C.
Antioxid Redox Signal. 2011 Sep 15;15(6):1477-96. doi: 10.1089/ars.2010.3454. Epub 2011 May 25.
PMID: 21395477
Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus.
Duparc T, Naslain D, Colom A, Muccioli GG, Massaly N, Delzenne NM, Valet P, Cani PD, Knauf C.
Antioxid Redox Signal. 2011 Feb 1;14(3):415-23. doi: 10.1089/ars.2010.3330. Epub 2010 Sep 29.
PMID: 20879900